Promotion to SPRF

A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells

S Hoves, VR Sutton, NM Haynes, ED Hawkins, DF Ruiz, N Baschuk, KA Sedelies, M Schnurr, J Stagg, DM Andrews, JA Villadangos, JA Trapani

2011-08-01

Granzymes A and B (GrAB) are known principally for their role in mediating perforin-dependent death of virus-infected or malignant..

Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L

S Konjar, VR Sutton, S Hoves, U Repnik, H Yagita, T Reinheckel, C Peters, V Turk, B Turk, JA Trapani, N Kopitar-Jerala

2010-10-01

The pore-forming protein perforin is synthesized as an inactive precursor in natural killer (NK) cells and cytotoxic T lymphocytes..

Cathepsin H is an additional convertase of pro-granzyme B

ME D'Angelo, PI Bird, C Peters, T Reinheckel, JA Trapaniand, VR Sutton

2010-07-02

The serine protease granzyme B (GrB) is the most potent proapoptotic cytotoxin of the granule exocytosis pathway of cytotoxic lymp..

Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis

VR Sutton, NJ Waterhouse, KA Browne, K Sedelies, A Ciccone, D Anthony, A Koskinen, A Mullbacher, JA Trapani

2007-02-12

Cathepsin C activates serine proteases expressed in hematopoietic cells by cleaving an N-terminal dipeptide from the proenzyme upo..